According to the Boston Globe, the marriage was set to end tumultuously after 16 years, following her bouts with alcohol and drugs -- a battle well known to her husband, who spoke openly about his own substance abuse problems. In 1984, he pleaded guilty to heroin possession and said he was born an alcoholic. In August 2010, Mary Kennedy was charged with driving under the influence of drugs, a month before she pleaded guilty to drunken driving and had her driver’s license suspended.
At the time of Mary's death, Kennedy was reportedly dating actress Cheryl Hines, who is known for her role as Larry David's wife "Cheryl" on HBO's Curb Your Enthusiasm. Hines' director of her then-new comic film Waitress was murdered a few months before the film was released in 2007.
The director was Adrienne Shelly (born Adrienne Levine). On November 1, 2006, after her husband found his wife Adrienne's body hanging by a bed sheet from a shower rod in their Manhattan West Village apartment's bathroom, the initial ruling was suicide. But the NYPD were suspicious of sneaker prints in the bathtub that did not match Adrienne Shelly's shoes (she was only wearing socks). Finally an arrest was made of Diego Pillico, a 19-year-old construction worker who confessed to the murder, and admitted he was "having a bad day."
1941 – Rosemary Kennedy is believed to have been mentally challenged. However, some sources have claimed she was suffering from mental illness, such as depression. Because of her increasingly violent and severe mood swings, her father, Joe, Sr., arranged in secret for her to undergo a lobotomy. The surgery impaired her cognitive abilities even more, and as a result, she remained institutionalized until her death in 2005.
August 12, 1944 - Joseph P. Kennedy, Jr. died when his plane exploded over East Suffolk, England as part of Operation Aphrodite.
May 13, 1948 – Kathleen Cavendish, Marchioness of Hartington died in a plane crash in France.
August 23, 1956 – Jacqueline Bouvier Kennedy gave birth to a stillborn daughter, Arabella. (Although the daughter was unnamed and is buried at Arlington National Cemetery next to her parents with a marker reading "Daughter", later reports indicated that the Kennedys had intended to name her Arabella.)
August 9, 1963 – Patrick Bouvier Kennedy died two days after his birth.
November 22, 1963 – U.S. President John F. Kennedy is assassinated by Lee Harvey Oswald in Dallas, Texas.
June 19, 1964 – U.S. Senator Edward M. Kennedy was involved in a plane crash in which one of his aides and the pilot were killed. He was pulled from the wreckage by fellow senator Birch E. Bayh II and spent weeks in a hospital recovering from a broken back, a punctured lung, broken ribs, and internal bleeding.
June 6, 1968 – U.S. Senator Robert F. Kennedy is assassinated by Sirhan Sirhan in Los Angeles immediately following his victory in the California Democratic presidential primary.
July 18, 1969 – In the Chappaquiddick incident, Ted Kennedy accidentally drove his car off a bridge in Chappaquiddick Island, fatally trapping his passenger Mary Jo Kopechne inside. In his July 25 televised statement, Kennedy stated that on the night of the incident he wondered "whether some awful curse did actually hang over all the Kennedys."
August 13, 1973 – Joseph P. Kennedy II was the driver of a car which crashed. His passenger Pam Kelley was permanently paralyzed.
November 17, 1973 – Ted Kennedy, Jr. lost a portion of his right leg due to bone cancer.
April 25, 1984 – David Kennedy died of a Demerol and cocaine overdose in a Palm Beach, Florida hotel room.
December 31, 1997 – Michael Kennedy died in a skiing accident in Aspen, Colorado.
July 16, 1999 – John F. Kennedy, Jr. died when the Piper Saratoga light aircraft he is piloting crashed into the Atlantic Ocean off the coast of Martha's Vineyard due to pilot error.
September 16, 2011 - Kara Kennedy Allen died of a heart attack while exercising in a Washington, D.C. health club.
May 16, 2012 - Mary Richardson Kennedy, the estranged wife of Robert F. Kennedy, Jr. is found dead of a suicide at the age of 52 in an "outbuilding" on her property near Bedford, New York. (See above for further details.)