Jerry Organ, who compiled the following visual overview of the episode, noted, "Weld is distantly related to Charles J. Guiteau, who assassinated President James A. Garfield."
Kenn Thomas notes about the episode entitled "Aren’t You Surprised To See Me?" that "it opens at Love Field and someone on the phone mentions Earle Cabell, Dallas mayor whose brother Charles was fired from the CIA by JFK over the Bay of Pigs. Earle Cabel is the person who changed the route of Kennedy's motorcade for November 22, 1963...JFK was headed for the Trade Mart [when he was assasinated] where Buz gets a job in this episode."
Organ also posted this:
I'm Here to Kill a King
The fourth season has the show's most-direct "connection" to the Kennedy Assassination: the "I'm Here To Kill A King" episode scheduled to run Nov. 29, 1963. Some sources claim the episode aired March 20, 1964 (the week after the series finale); it certainly made it into syndication. The episode scheduled to run Nov. 22nd ("Kiss the Monster, Make Him Sleep" filmed in Minneapolis with James Coburn) was pre-empted and ran Jan. 24, 1964.
The "King" episode--with Robert Loggia, Tina Louise and Frank Campanella--was one of two from the series that were set in Canada. A close confident of the King of an oil-rich Middle-Eastern country hires a mercenary to assassin the leader while visiting the world-famous Niagara Falls. Tod is working at the Falls when he is mistakenly given an itinerary because he looks near-identical to the "assassin" character (Milner in a dual role). Word gets back to the plotters, who then attempt to frame Tod as the assassin by kidnapping Tod and having the "assassin" take his place at Tod's work-site.
Among the "King" episode's purported similarities: the assassin plans to shoot the King through the head, a character's father name is Lee, the King deplanes and travels in a motorcade, the assassin uses a rifle and intends to fire from a knoll. Dallas is mentioned as a place for the King to discuss oil deals.
Martin Milner seems to bear somewhat of a resemblance to Texas Tower sniper Charles Whitman.